Leaky gut and the liver: A role for bacterial translocation in nonalcoholic steatohepatitis
نویسندگان
چکیده
منابع مشابه
The Gut Microbiota, Intestinal Permeability, Bacterial Translocation, and Nonalcoholic Fatty Liver Disease: What Comes First?
onalcoholic fatty liver disease (NAFLD) is one of the Nleading causes of chronic liver disease in the United States, and its prevalence is rising in the developed as well as in the developing world. Although tremendous headway has been made in understanding the pathogenesis of NAFLD, the role of the gut microbiota and intestinal permeability in augmenting disease progression from nonalcoholic f...
متن کاملNonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is a well-recognized form of chronic liver disease affecting both children and adults that has gained increased recognition. Recently NAFLD has been associated with insulin resistance and its incidence and prevalence is likely increasing, paralleling the rise in obesity and diabetes mellitus in the United States. The article includes current thoughts on ...
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Background: Fatty liver (FL) is the most common liver disease but its clinical significance remains elusive. Nonalcoholic steatohepatitis (NASH) is increasingly recognized as a cause of liver failure, sometimes recurring following transplantation. Recent data on both conditions are critically reviewed. Methods: A Medline search of the medical literature (1990 to September 1998) and cross-refere...
متن کاملDetermination of certain bacterial groups in gut microbiota and endotoxin levels in patients with nonalcoholic steatohepatitis.
BACKGROUND/AIMS In recent years, the role of the gut microbiota has emerged in several diseases. Herein we aimed to determine the fecal microbiota, endotoxin levels, and inflammation markers in patients with nonalcoholic steatohepatitis (NASH) and healthy controls. MATERIALS AND METHODS A total of 46 NASH patients and 38 healthy controls were included. NASH patients were diagnosed according t...
متن کاملRodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Research in nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), has been limited by the availability of suitable models for this disease. A number of rodent models have been described in which the relevant liver pathology develops in an appropriate metabolic context. These models are promising tools for researchers investigating one of the key issues of NASH...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2012
ISSN: 1007-9327
DOI: 10.3748/wjg.v18.i21.2609